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given that your data frame is named veryVeryVERYLargeDF
lapply(colnames(veryVeryVERYLargeDF)[2:ncol(veryVeryVERYLargeDF)], function(nameOFColumnInveryVeryVERYLargeDF) cbind(veryVeryVERYLargeDF$ID, veryVeryVERYLargeDF[,nameOFColumnInveryVeryVERYLargeDF]))
that will give you a list of somewhatSmallerDFs, where each somewhatSmallerDF is simply the ID column from veryVeryVERYLargeDF and one of the other columns from veryVeryVERYLargeDF
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solved How to create multiple data frames from a huge data frame using a loop? [closed]