Telepathic power: you are talking about size of file on disk and comparing original compressed file (likely JPG) with cropped version saved in non-compressed format (likely BMP).
Fix: save cropped image in compressed format.
Image.Save with 2 arguments lets you specify format (i.e. unlike one argument version you use in your sample).
Example from the article:
// Construct a bitmap from the button image resource.
Bitmap bmp1 = new Bitmap(typeof(Button), "Button.bmp");
// Save the image as a GIF.
bmp1.Save("c:\\button.gif", System.Drawing.Imaging.ImageFormat.Gif);
2
solved Size of image increases after cropping