So I assume you are looking to do this in SAS.
In PROC REG, use the restrict statement to fix a coefficient.
proc reg data=sashelp.cars;
/*Fit unrestricted*/
model msrp = horsepower weight;
run;
/*Fit restricted*/
model msrp = horsepower weight;
restrict horsepower=250;
run;
quit;
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solved Regression with constrained coeffcient Using SAS [closed]