No, you cannot have exactly that. However, if there some reason why you really need to have a string at the beginning of a line (and note that this not a recommended style at all in Python), you can write:
''' This line is imperative: '''; x = 5
Note the ;
after the string. This works because ''' This line is imperative: '''
and x = 5
are effectively two statements that can be concatenated in one line in Python with a semicolon.
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solved Is it possible to put a comment at the beginning of a line in python?