Try this:
import tkinter as tk
root = tk.Tk()
root.geometry("500x300+10+13")
root.title("Test")
b = tk.Button(root, text="click me")
def onclick(evt):
w = evt.widget
w.destroy()
b.bind("<Button-1>", onclick)
b.pack()
root.mainloop()
13
solved How to destroy widgets?