MySQLdb (the native driver for MySQL) is not compatible with Python3 yet; but the driver from Oracle for MySQL, called MySQL Connector/Python is compatible with Python 3.
You should use the Oracle driver. django works with both.
Once you have the driver installed, follow the connection section in the documentation.
solved Django 1.6.1 + MySQL + Apache 2.4.7 on Windows. Is it possible? [closed]