You can modify your script like this. Since you are checking the grade for greater than 80 in the else part, you need not to use && operator. Also your braces were missing.
<script>
function myFunction() {
var grade=document.getElementById("txtgrade");
if (grade.value >= 90) {
document.getElementById("demo").innerHTML = "Letter Grade is 'A'";
} else if (grade.value >= 80) {
document.getElementById("demo").innerHTML = "Letter Grade is 'B'";
}
}
</script>
solved Java Script Logical Operator In IF ELSEIF Statement [closed]